Here's the latest on all the major injuries from our NFL Nation reporters, including the prognosis on each player for Week 12 and beyond:
Alex Smith, QB, Washington Redskins
Smith suffered two broken bones in his right leg in the third quarter of Sunday's 23-21 loss to the Texans. After Washington initially classified it as an ankle injury, coach Jay Gruden confirmed after the game that Smith had broken his tibia and fibula and would need immediate surgery. The Redskins have only one other quarterback on the roster in Colt McCoy, who threw a touchdown pass on the ensuing series after replacing Smith, but are planning to bring in other QBs for a tryout on Monday. -- John Keim
Marcus Mariota, QB, Tennessee Titans
Mariota's elbow injury is of utmost concern. It's the same elbow that suffered nerve damage earlier this season, which kept him from being able to grasp a football. Mike Vrabel said Mariota told him that he was all right, but the coach still went with Blaine Gabbert in the second half of the loss to Indianapolis. Vrabel didn't offer any update on Mariota after the game. -- Turron Davenport
Kerryon Johnson, RB, Detroit Lions
Johnson injured his knee in the third quarter against Carolina, and didn't return. The Lions had no updates after the game, but Johnson was not spotted in the locker room and his locker had been cleaned out by the time the media entered. If Johnson were to miss any period of time, Detroit would likely look to a combination of LeGarrette Blount, Theo Riddick and Zach Zenner to fill his role, although none has the complete set of abilities he possesses. -- Michael Rothstein
Jimmy Graham, TE, Green Bay Packers
Graham left the Packers' loss to the Seahawks during the first half with a thumb injury, and didn't return. Tests on the injured digit on Friday revealed it is broken. The Packers used Lance Kendricks almost exclusively in his place, but coach Mike McCarthy said rookie Robert Tonyan could see his playing time increase if Graham misses significant time. McCarthy was unsure whether Graham would be available for Week 12 against the Vikings. -- Rob Demovsky
Brandon LaFell, WR, Oakland Raiders
The Raiders fear LaFell tore his Achilles tendon while making an acrobatic 24-yard catch in Oakland's 23-21 defeat of the Cardinals. Lafell -- who had risen to the top of Oakland's WR depth chart with the Oct. 22 trade of Amari Cooper to the Cowboys and knee injuries to Jordy Nelson and Martavis Bryant last week -- had two catches for 29 yards, including a five-yard TD, against Arizona. The three healthy wideouts for the Raiders on their game winning-drive were Seth Roberts and rookies Marcell Ateman, a seventh-round draft pick, and Saeed Blacknall, an undrafted rookie. Asked about his depleted receiver group, Raiders QB Derek Carr said, "It's like Thanos snapped his fingers and they disappeared." -- Paul Gutierrez
Corey Liuget, DT, Los Angeles Chargers
Chargers coach Anthony Lynn said that Liuget is out for the year with a right knee injury. Liuget suffered the injury in the first half, and did not return to the field. The Florida native had been playing well since returning from a four-game suspension for violating the league's policy on performance-enhancing drugs. The Chargers already lost Denzel Perryman for the year with a knee injury, so losing Liuget is another blow to the Bolts' ability to stop the run. -- Eric D. Williams
Bradley Roby, CB, Denver Broncos
Roby may have suffered a concussion in the second half of the Broncos' win over the Los Angeles Chargers, and will be evaluated again on the team's return to Denver. But he could begin the practice week in the concussion protocol, and miss some practice time. -- Jeff Legwold
Tyron Smith, OT, Dallas Cowboys
Left tackle Tyron Smith suffered a stinger with 34 seconds to play on the Cowboys' game-winning drive. Smith said after the game he was "tender," but was feeling better than he had from stingers suffered earlier in his career. With a quick turnaround coming against Washington on Thursday, the Cowboys will not hold a live practice, which could help the injury calm down over the next few days. If he can't play, then veteran Cameron Fleming would make his first start of the season. Fleming filled in briefly for right tackle La'el Collins and had a key block on Ezekiel Elliott's touchdown run. -- Todd Archer
Andrus Peat and Larry Warford, OG, New Orleans Saints
Starting guards Warford and Peat both left the game in the second half, but Warford's head injury was not a concussion. It's unclear if either is in jeopardy of missing Thursday's game against Atlanta. The Saints may have just been being cautious with Peat, who was in and out of the lineup after dealing with recent injuries. -- Mike Triplett
Zach Fulton and Senio Kelemete, OG, Houston Texans
The Texans lost both starting guards, Fulton (shoulder) and Kelemete (ankle), in the first half. Texans head coach Bill O'Brien said he didn't think either of the injuries was "serious," but that he would know more on Monday. On Sunday, guard Greg Mancz filled in at right guard for Fulton, while rookie tackle Martinas Rankin played at left guard in place of Kelemete. Mancz has started three games at guard this season and has played well. -- Sarah Barshop
A.J. Cann, OG, Jacksonville Jaguars
Starting RG Cann left the game with a hamstring injury on the last play of the first quarter, which left the Jaguars with three backup offensive linemen on the field (including the fourth-string left tackle). That could be the lineup going forward, too, because two of the injured starters are gone for the season. Chris Reed replaced Cann and had a lot of trouble with NT Javon Hargrave (two sacks). -- Michael DiRocco