The Indianapolis Colts have waived Week 1 starter Deon Jackson and signed running back Trey Sermon from the practice squad, the team announced Saturday.
Jackson rushed for just 14 yards on 13 carries and gained only 14 yards on five receptions in the season-opening 31-21 loss to the Jacksonville Jaguars on Sept. 10.
Zack Moss got the start in Week 2 at Houston. He gained 107 yards from scrimmage on 22 touches and scored on an 11-yard run in the Colts' 31-20 victory.
With 2021 NFL rushing champion Jonathan Taylor still on the physically unable to perform list, Moss will remain the RB1 for the Colts (1-1) on Sunday against the Baltimore Ravens (2-0).
Jackson, 24, rushed for 281 yards and two touchdowns and caught 35 passes for 223 yards and one score in 27 games (three starts) over the past three seasons in Indianapolis. He was undrafted out of Duke in 2021.
Sermon, 24, was a third-round pick by the San Francisco 49ers in 2021. He has rushed for 186 yards and one touchdown and has three receptions for 26 yards in 11 games (two starts) with the 49ers (2021) and Philadelphia Eagles (2022).