Cleveland Browns wide receiver Jakeem Grant was carted off the field after suffering a "significant" right knee injury on the opening kickoff of Saturday's preseason game against the host Kansas City Chiefs, coach Kevin Stefanski said.
Stefanski also said Browns Pro Bowl CB Denzel Ward is in concussion protocol after the 33-32 loss.
The medical staff placed an air cast around Grant's leg before driving him into the locker room.
The 2021 Pro Bowler had just returned from a season-ending Achilles injury suffered during training camp last year.
Chiefs quarterback Patrick Mahomes, Grant's college teammate at Texas Tech, was among those with Grant as he was loaded onto the cart.
ESPN's Adam Teicher contributed to this report.