Henry Slade will start for England at inside centre against Argentina on Saturday with Eddie Jones opting to rest both Owen Farrell and Maro Itoje.
Jones has spoken before of his plan to rest some of those who played for the British & Irish Lions in the summer and while Farrell and Itoje will sit out Saturday's Test, he has turned to Anthony Watson, Elliot Daly, Mako Vunipola and George Kruis for their opening Test of the autumn programme.
Daly gets the nod on the wing having made a rapid recovery from a knee injury, but Jonny May misses out with a hamstring strain. Mike Brown starts at fullback with Watson on the other wing but with Farrell rested, Slade gets the nod at inside centre with Jonathan Joseph outside him.
George Ford and Ben Youngs start in the half backs while there is a familiar look to the pack with Mako Vunipola, captain Dylan Hartley and Dan Cole starting in the front-row. Courtney Lawes and George Kruis start in the locks with Chris Robshaw, Sam Underhill and Nathan Hughes in the back-row.
Ellis Genge, Harry Williams, Alex Lozowski and Semesa Rokoduguni are all on the bench. Tom Curry was originally named among the replacements but has since been replaced by Sam Simmonds due to a wrist injury.
"As a squad we have been preparing for this game since our first camp in August and are excited about playing in front of 82,000 fans at Twickenham Stadium on Saturday," Jones said. "This is our best 23 selected in what is our most important game this year.
"We know that Argentina is a strong team -- Rugby World Cup semi finalists in 2015 -- and we will have to be smart and play well to beat them."
England team to face Argentina:
Brown, Watson, Joseph, Slade, Daly, Ford, Youngs; M. Vunipola, Hartley (captain), Cole, Lawes, Kruis, Robshaw, Underhill, Hughes.
Replacements: George, Genge, Williams, Launchbury, Simmonds, Care, Lozowski, Rokoduguni