Last year's beaten finalists SuperSport United from South Africa have received a bye in the first round of the CAF Confederation Cup, but face a potentially difficult second round clash.
SuperSport await the winner of the first round tie between Petro Atletico (Angola) and Masters Security Services (Malawi), with the Angolans expected to advance.
Whoever makes it past the second stage will face a play-off with the 16 teams that lose in the African Champions League second round in order to reach the group stages.
SuperSport are one of 10 clubs given a bye into the second round, along with USM Alger (Algeria), Zamalek (Egypt), Raja Casablanca (Morocco), Enyimba (Nigeria), DC Motema Pembe (DR Congo), Al Ahly Shandy (Sudan), Al Hilal Obied (Sudan), Club Africain (Tunisia) and Nkana (Zambia).
Zamalek will be confident of making the play-off stage as they face the winner of the tie betweenZimamoto (Zanzibar) and Wolaitta Dicha (Ethiopia).
Three-time Champions League winners Raja await the victors in the tie between Africa Sports (Ivory Coast) and FC Nouadhibou (Mauritania), while Club Africain have a potentially tough outing against either Renaissance Berkane (Morocco) or Mbour Petite Cote (Senegal).
South African debutants Cape Town City make their bow in the first round against Young Buffaloes of Swaziland.
The first round ties will be played on the weekends of February 9-11 and 16-18, with the second round to take place on March 9-11 and 16-18.
The play-off stage will take place on the weekends of April 6-8 and 13-15.
The group phase will begin in early May and conclude in the middle of September, with a two-and-a-half month break for the FIFA World Cup.
FIRST ROUND DRAW
Petro Atletico (Angola) v Masters Security Services (Malawi)
Young Buffaloes (Swaziland) v Cape Town City (South Africa)
Costa do Sol (Mozambique) v Jwaneng Galaxy (Botswana)
Benin representative v Hafia (Guinea)
APR FC (Rwanda) v Anse Reunion (Seychelles)
Onze Createurs (Mali) v Elwa United (Liberia)
AFC Leopards (Kenya) v Fosa Juniors (Madagascar)
Ngazi Sport (Comoros Islands) v AS Port Louis 2000 (Mauritius)
Mangasport (Gabon) v Maniema Union (DR Congo)
Olympic Star (Burundi) v Etoile Filante (Burkina Faso)
New Stars (Cameroon) v CD Niefang (Equatorial Guinea)
AS Tanda (Ivory Coast) v CS La Mancha (Congo)
Akwa United (Nigeria) v Hawks (Gambia)
Al Ittihad (Libya) v Sahel SC (Niger)
US Ben Guerdane (Tunisia) v Al Hilal Juba (South Sudan)
Asante Kotoko (Ghana) v CARA Brazzaville (Congo)
Djoliba (Mali) v Chabab Belouizdad (Algeria)
Al Masry (Egypt) v Green Buffaloes (Zambia)
Simba SC (Tanzania) v Gendarmerie Tnale (Djibouti)
Renaissance Berkane (Morocco) v Mbour Petite Cote (Senegal)
Africa Sports (Ivory Coast) v FC Nouadhibou (Mauritania)
Zimamoto (Zanzibar) v Wolaitta Dicha (Ethiopia)
SECOND ROUND DRAW
Petro Atletico or Masters Security Services v SuperSport United (South Africa)
Costa do Sol or Jwaneng Galaxy v Young Buffaloes or Cape Town City
Benin representative or Hafia v Enyimba (Nigeria)
Onze Createurs or Elwa United v APR FC or Anse Reunion
Ngazi Sport or AS Port Louis 2000 v AFC Leopards or Fosa Juniors
Mangasport or Maniema Union v USM Alger (Algeria)
Olympic Star or Etoile Filante v Al Hilal El Obeid (Sudan)
DC Motema Pembe (DR Congo) v New Stars or CD Niefang
AS Tanda or CS La Mancha v Al Ahly Shandi (Sudan)
Al Ittihad or Sahel SC v Akwa United or Hawks
Asante Kotoko or CARA Brazzaville v US Ben Guerdane or Al Hilal Juba
Djoliba or Chabab Belouizdad v Zanaco (Zambia)
Simba SC or Gendarmerie Tnale v Al Masry or Green Buffaloes
Renaissance Berkane or Mbour Petite Cote v Club Africain (Tunisia)
Raja Casablanca (Morocco) v Africa Sports or FC Nouadhibou
Zimamoto or Wolaitta Dicha v Zamalek (Egypt)