Real Madrid will travel to Spain's African enclave of Melilla to open the Copa del Rey.
Madrid were paired with third-division club UD Melilla in Friday's draw, the first to include the top two tiers of Spanish clubs.
Defending champion Barcelona will face third-division side Leonesa, while Atletico Madrid drew fourth-tier club Sant Andreu.
The first legs will be played at the smaller club's stadium between Oct. 31 and Nov. 1. The return legs will be held between Dec. 4 and 6.
Melilla and Ceuta are Spain's two enclaves on the northern African coast.