Leicester pair Manu Tuilagi and Ben Youngs have pulled out of the latest England training camp after sustaining injuries in Premiership action, the Rugby Football Union has confirmed.
Centre Tuilagi and scrumhalf Youngs suffered "niggles" in Leicester Tigers' 44-37 defeat to Worcester Warriors on Sunday and will now not take part in head coach Eddie Jones' camp this week in Bristol.
A Tigers spokesperson said they will be assessed at the club over the next few days while the injuries would keep them out of training at the start of the week.
Worcester prop Nick Schonert has also withdrawn with an injury picked up in the same match, while Harlequins prop Joe Marler has dropped out for personal reasons.
Tuilagi, who has not played for England for more than two years, had been the latest surprise recall to the squad when it was named last Thursday.
The Samoa-born centre has won 26 caps for England and scored 11 tries, but has seen his international prospects hindered by a spate of injuries and disciplinary problems.
At 27, he has played just 45 matches in 5 seasons for Leicester with knee and groin problems to blame for his inconsistent appearance record.
Off the pitch he has been sent home from several England squads -- most recently in August 2017 for returning to the team hotel drunk after a night out.
Tuilagi's club-mate Jordan Olowofela, 20, will be added to the squad in his place at centre with Exeter Chiefs prop Ben Moon also brought in, an RFU statement said.
Jones will name his squad for the home November tests against South Africa, New Zealand, Japan and Australia on Oct. 18 before taking his players to Portugal for another training camp.