Warren Gatland has rung the changes for the visit of Georgia Saturday, with four players set to make their first Wales start.
Leon Brown, Adam Beard, Sam Cross and Owen Watkin will all start their first Test match, while Rhys Webb returns to the team following injury.
However, back row Justin Tipuric is still not fit enough to return meaning Cross takes the No. 7 shirt, alongside captain Dan Lydiate and No. 8 Seb Davies.
Liam Williams, the sole survivor from last weekend's defeat to Australia, switches to fullback for Saturday's game and is joined in the back three by Hallam Amos and Alex Cuthbert.
Scott Williams, originally omitted from Wales' autumn squad, is recalled in midfield to partner Watkin, while Webb and Rhys Priestland start at half-back.
Hooker Elliot Dee is set to make his debut having been named on a strong replacements' bench, that also includes Taulupe Faletau, Dan Biggar and Owen Williams.
Wales team to play Georgia:
L. Williams, Cuthbert, S. Williams, Watkin, Amos, Priestland, Webb; Smith, Dacey, Brown, Beard, Hill, Lydiate (captain), Cross, S. Davies.
Replacements: Dee, W. Jones, Francis, Navidi, Faletau, A. Davies, Biggar, O. Williams.