Here are the most significant NFL injuries in Week 10:
Curtis Samuel, WR, Carolina Panthers: Samuel left the game in the third quarter with an ankle injury after dropping a would-be touchdown pass in the end zone. He was spotted on crutches after the game, and Cam Newton said of the injury, "it's bad. It's real bad."
On Tuesday, Panthers coach Ron Rivera indicated that Samuel will undergo an MRI on the ankle, and acknowledged there is concern it could be a season-ending injury. Those concerns were validated, as the team announced Samuel will miss the rest of the season due to ligament damage in his ankle.
Devonta Freeman, RB, Atlanta Falcons: Freeman departed to the locker room after taking a hit from Cowboys LB Anthony Hitchens. The team declared him questionable to return because of a head injury before downgrading him to out and noting he is now in the NFL's concussion protocol.
With Freeman out, Tevin Coleman took over duties as the Falcons' primary running back.
Will Fuller V, WR, Houston Texans: Fuller was shaken up after taking a hard hit from Rams safety Lamarcus Joyner in the first half and was helped off the field by a trainer before heading back to the locker room. The Texans declared him questionable to return because of a rib injury before downgrading him to out.
D.J. Fluker, OL, New York Giants: Already down Justin Pugh, the Giants witnessed Fluker limp to the sideline in the third quarter. He was declared questionable to return and replaced in the lineup by Jon Halapio.
Sean Lee, LB, Dallas Cowboys: Lee exited Sunday's game late in the first quarter after aggravating a hamstring issue with which he's been dealing this season. He was declared questionable to return before being downgraded to out. Jaylon Smith took over for Lee in the lineup.
Joe Haden, CB, Pittsburgh Steelers: Haden fell awkwardly after colliding with Donte Moncrief near the end of the first quarter and had to be helped off the field. He was brought to the medical tent on the sideline, then to the locker room for further evaluation of his left leg. Coty Sensabaugh replaced him in the lineup. The Steelers deemed him questionable to return, but he was then downgraded to out early in the third quarter.
After the game, Steelers coach Mike Tomlin indicated the Haden suffered a broken fibula and is out indefinitely.
Aaron Jones, RB, Green Bay Packers: A knee injury befell Jones during the first quarter against the Bears, and he was carted off to the locker room. The club designated him questionable to return, before later downgrading him to out. Per ESPN's Rob Demovsky, there is concern that it could be a significant injury. Ty Montgomery took over as the primary rusher after Jones' exit but was then knocked out of the game himself.
On Monday, ESPN's Adam Schefter reported that Jones will miss three to six weeks with an MCL injury.
Ty Montgomery, RB, Green Bay Packers: After battling broken ribs earlier this season, Montgomery was knocked out of the game against the Bears with a rib injury again. Given that Aaron Jones is also out, Jamaal Williams and fullback Aaron Ripkowski are next men up for the Packers' backfield.
DeShone Kizer, QB, Cleveland Browns: Kizer was knocked out of the game after taking a brutal hit to the ribs from Lions CB Quandre Diggs in the third quarter. He remained down on the field before being helped off and into the locker room for further evaluation; he was declared questionable to return. Cody Kessler took over for Kizer at QB.
Jacoby Brissett, QB, Indianapolis Colts: Brissett was removed from the game briefly under a barrage of hard hits, including one after which he appeared woozy. Backup Scott Tolzien went on the field to begin the next series, only to have Brissett run on to the field to replace him.
Though Brissett did not enter the NFL's concussion protocol during the contest, the Colts announced after the game that he was now in the protocol.
Jeff Allen, OG, Houston Texans: Allen exited the game early in the first quarter and went to the locker room with Texans medical personnel. He was replaced in the lineup by Greg Mancz. Allen was declared probable to return with a hand injury.
Morris Claiborne, CB, New York Jets: Battling a nagging foot injury in recent weeks, Claiborne took himself out during the first half against the Bucs. After halftime, Claiborne remained out of the game, and the team declared him doubtful to return because of the foot issue.
Adam Jones, CB, Cincinnati Bengals: Jones was removed from the game late in the third quarter to be evaluated for a concussion. Early in the fourth quarter, he was ruled out for the remainder of the game.
Deshazor Everett, S, Washington Redskins: After sustaining an eye injury late in the second quarter against the Vikings, Everett was taken to the locker room. The Redskins declared him questionable to return.
Shareece Wright, CB, Buffalo Bills: Wright was shaken up after making a play on Saints WR Brandon Coleman during the second quarter and left the field with some assistance. He returned to the game shortly thereafter.
Rob Kelley, RB, Washington Redskins: Kelley appeared to suffer a leg injury as he was tackled late in the first quarter. He was declared questionable to return with a knee/ankle injury but was downgraded to doubtful in the third quarter.
On Monday, head coach Jay Gruden indicated that Kelley will miss multiple games due to his injuries.
Jamie Collins Sr., LB, Cleveland Browns: In the course of making a tackle in the first quarter of the game against the Lions, Collins knee appeared to bend awkwardly, and he was removed from the game. The Browns declared him questionable to return, but downgraded him to out early in the second half.
On Monday, the team revealed that Collins will miss the rest of the season due to an MCL injury.
Ryan Grant, WR, Washington Redskins: Grant left the game in the first quarter and was placed in the concussion protocol. After initially clearing Grant, the Redskins medical staff elected to run more tests and subsequently ruled Grant out for the remainder of the game.
Darrius Heyward-Bey, WR, Pittsburgh Steelers: Heyward-Bey sustained a left foot injury during the first quarter of Sunday's game against the Colts, and he was deemed questionable to return. The speedster made his return on the Steelers' final drive of the first quarter.
Richard Sherman, CB, Seattle Seahawks: Sherman exited the game in the third quarter of the Seahawks' win over the Cardinals and did not return after suffering a ruptured Achilles tendon. He will miss the remainder of the season.
Duane Brown, OT, Seattle Seahawks: Playing in just his second game for the Seahawks after a trade from the Texans, Brown left the game late in the second quarter against the Cardinals because of an ankle injury. He did not return, and Matt Tobin replaced him at left tackle.
Drew Stanton, QB, Arizona Cardinals: Stanton, playing in place of the injured Carson Palmer, sustained a knee sprain during the club's loss to the Seahawks, per ESPN's Chris Mortensen. He is expected to miss a week or two, and Blaine Gabbert will step in as the starter if Stanton cannot play in Week 11.