The rise of Thomas Partey in recent months ensures that Saturday's Madrid derby will take on an extra twist in Ghana.
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Asamoah Gyan is set to add an airline to his ever-expanding business empire as he aims to avoid the fate of many ex-footballers when he stops playing.
Ghana boss Kwesi Appiah has defended his continuous exclusion of the Ayew brothers from the Black Stars.
Despite not qualifying for the 2018 World Cup, there are positives for the Black Stars to take from the failure.
KweséESPN picks out the five biggest African disappointments of the World Cup qualifying campaign.
Edwin Gyasi's first Ghana goal cancelled out Shikabala's opener as the Black Stars end their World Cup qualifying campaign with a draw against Egypt.
Ghana are already out of the running for the World Cup, but Kwesi Appiah still believes there's a lot at stake in their final qualifier against Egypt.
Ghana international Thomas Partey has told KweséESPN how Diego Simeone's tutelage has allowed him to progress at Atletico Madrid.
Atletico Madrid midfielder Thomas Partey has cited instability as the primary reason why Ghana failed to qualify for the World Cup.
Former teammates of the late Yakubu Abubakari have paid tribute to a player who was "everything a manager would want" according to Aaron Mokoena.
Former Ghana and Ajax midfielder Yakubu Abubakari has died aged 36.
Mubarak Wakaso has been recalled by Ghana for their final World Cup qualifier against Egypt, but there is still no place for the Ayew brothers.
Ghana U-17 coach Paa Kwesi Fabian believes graduates of the squad who reached the final eight of the U-17 World Cup can enjoy successful careers.
FIFA says it will not act on Ghana's complaint about refereeing in a World Cup qualifying match last weekend.
Ghana international Raphael Dwamena believes that he returns to action a stronger character after missing out on a move to the Premier League.
Cranes skipper Denis Onyango has complained that the nation's authorities are not serious about football after their draw with Ghana on Saturday.
Ghana and Uganda played out a dour goalless draw in Kampala on Saturday which dents the pair's hopes of World Cup qualification.
Fans urged Kwesi Appiah to act after a poor World Cup qualifier against Congo in Kumasi - and so he did with a squad heavy on big-name omissions.
Ghana coach Kwesi Appiah has dropped Andre and Jordan Ayew for the 2018 FIFA World Cup qualifier against the Cranes of Uganda.
Ghana defeated Nigeria 4-1 in the 2017 WAFU Cup of Nations final on Sunday, avenging an earlier group stage defeat to the Super Eagles.
Ghana captain Asamoah Gyan is adamant he still has a lot to contribute to the Black Stars as the debate over his continued selection intensifies.
Boateng revealed a tribute to the Ajax midfielder, who is recovering from a cardiac arrhythmia attack, after scoring on Saturday.
Kwesi Appiah needs to act now in order to qualify for Russia next year as the Black Stars play catch up with leaders Egypt and Uganda.
Thomas Partey scored a hat-trick and Richmond Boakye netted twice as Ghana defeated Congo-Brazzaville 5-1 to revive their faint World Cup hopes.
Ex-Ghana boss Milovan Rajevac will call on his experience of facing Australia in the 2010 World Cup when he guides Thailand in Melbourne on Tuesday.