Kara Mbodji scored a late winner as Senegal sealed a 2-1 victory over South Africa in Dakar to absolutely confirm their World Cup qualification.
Nigeria's players and football federation signed a landmark agreement concerning the payment structure for World Cup bonuses on Tuesday.
Despite not qualifying for the 2018 World Cup, there are positives for the Black Stars to take from the failure.
KweséESPN identify the five matches which ultimately decided Africa's World Cup qualifiers.
Who were the continent's star performers during the weekend's qualifiers?
Stuart Baxter insists it is important for South Africa to finish their qualifying campaign with a flourish against Senegal on Tuesday.
While several of Africa's top names will be present at the World Cup, many have been left behind.
Edwin Gyasi's first Ghana goal cancelled out Shikabala's opener as the Black Stars end their World Cup qualifying campaign with a draw against Egypt.
The North Africans confirmed their berth in Russia after drawing 0-0 with Libya in Rades, ending the Democratic Republic of Congo's World Cup hopes.
Morocco ended their two-decade wait for a World Cup ticket by beating Ivory Coast 2-0 in Abidjan on Saturday.
Morocco stunned Ivory Coast 2-0 to qualify for the 2018 World Cup, while Tunisia also booked their ticket to Russia on Saturday.
Striker Nelson Senkatuka has revealed his delight at returning to the Uganda squad for the Cranes' World Cup qualifier away at Congo-Brazzaville.
Yaya Banana headed home a stoppage-time equaliser as Cameroon ended their World Cup qualifying campaign with a 2-2 draw in Zambia.
How did the Super Eagles fare in their final World Cup qualifier against Les Fennecs in Constantine?
Yacine Brahimi converted a late and controversial penalty to secure a 1-1 home draw for Algeria to deny Nigeria victory in the final qualifier.
How did Senegal and South Africa's players fare in Friday's World Cup qualifier in Polokwane?
South Africa coach Stuart Baxter believes his side are progressing despite their failure to reach the 2018 World Cup in Russia.
Two of the five available World Cup places have been confirmed in Africa, with the final three places decided in November.
Senegal became the third African country to qualify for the 2018 World Cup by defeating South Africa 2-0 on Friday.
How well do you know the history of World Cup qualification? Test your knowledge ahead of this week's crucial playoffs.
Marc Wilmots has struggled as Ivorian head coach, but could redeem himself with World Cup qualification...if he finds a way past his predecessor.
Which of the continent's players look set to play decisive roles in the World Cup qualifiers this weekend?