El Tri has emerged from October's friendlies with a number of lessons learnt. With a focus on those two matches, here is the latest Mexico hot-list:
Liverpool have been hit hard during the international break with Naby Keita, Sadio Mane, Mohamed Salah and Virgil van Dijk all picking up injuries.
Hirving Lozano is already a star for Mexico, but he isn't the only player who can go on to shine at the next World Cup.
Against Peru, each player showed flashes of the kind of ability that has the U.S. fan base excited. Just don't expect too much too soon.
Dave Sarachan expressed disappointment over the United States' 1-1 draw, but also acknowledged that his youthful side competed well against Peru.
Mexico couldn't get the desired result against Chile, but the positives outweighed the negatives on another informative and experimental night.
Nicolas Castillo's late second-half goal gave Chile a 1-0 victory over Mexico in a friendly on Tuesday night.
The young U.S. attack hinted at what it could be one day, but failure to keep possession and late-game inexperience proved costly vs. Peru.
Edison Flores scored a late second-half goal for Peru as the United States settled for a 1-1 draw against the South American side on Tuesday night.
The United States men's soccer team's Nov. 20 friendly against Italy will take place in Beligum, it was announced on Tuesday.
Brazil and Argentina are at very different stages of development, which is why the Selecao should be concerned by the manner of their narrow win.
Denmark midfielder Lukas Lerager scored his first international goal and Martin Braithwaite added a late second to wrap up a 2-0 win over Austria.
Sweden striker John Guidetti scored his first international goal in more than two years as they drew 1-1 with Slovakia.
Netherlands forward Arnaut Groeneveld scored his first international goal to secure a 1-1 draw at neighbours Belgium in a friendly on Tuesday.
A stoppage-time goal from Miranda gave Brazil a 1-0 win over South American rivals Argentina in a foul-laden friendly in Saudi Arabia on Tuesday.