The big match of this weekend comes at Wembley, as the first major piece of silverware is handed out in the Carabao Cup final.
Amazingly, Arsenal boss Arsene Wenger has never won the competition in all his years in England. Will he end that run on Sunday, or will Manchester City take the first of what will surely be a minimum of two trophies this season?
Back in the Premier League, and it's the face-off between Jose Mourinho and Antonio Conte as Chelsea make the trip to take on Manchester United at Old Trafford. There's no love lost between the two coaches, but who will get the bragging rights this time?
Tottenham will look to take advantage of Arsenal being in cup action, as well as United and Chelsea playing each other, by taking three points off Crystal Palace. And the same goes for Liverpool, who will be hot favourites when they host West Ham United.
Predict those games, and the rest of the weekend's action, in our polls.
At the other end of the table, West Brom meet Huddersfield in a game the Baggies surely have to win to give themselves a chance of staying up, while Brighton are at home to a resurgent Swansea City.