Uzair Cassiem will start at No 8 for the Springboks in their Rugby Championship opener against Argentina at the Nelson Mandela Bay Stadium in Port Elizabeth on Saturday.
The Cheetahs loose forward comes into the starting line-up for only his second Test after making his international debut last November against Wales in Cardiff. Jean-Luc du Preez moves to the bench after starting at the back of the scrum in the last match.
The other change in the pack that started the third Test against France in June sees the inclusion of experienced tighthead prop Coenie Oosthuizen in place of Ruan Dreyer.
Springbok coach Allister Coetzee made only one change to the backline, with scrumhalf Ross Cronje resuming the No 9 duties from Francois Hougaard. Hougaard and Du Preez are joined on the bench by experienced prop Trevor Nyakane, as well as Curwin Bosch, the promising young Sharks and Junior Springbok flyhalf, who will make his Springbok debut should he run onto the field on Saturday.
"Uzair is a very versatile loose forward and the added advantage is that he is also an excellent option in the lineout," Coetzee explained. "Coenie has played consistently well this season for the Cell C Sharks and he performed well for us whenever he came off the bench in the French series, while Trevor has worked extremely hard and deserves his opportunity."
Coetzee said that Bosch had slotted well into the Springbok environment during his stay of almost two weeks with the squad in Port Elizabeth. The youngster also attended the Boks' pre-season training camp in April.
"Curwin is a young player with huge potential and a bright future ahead of him," Coetzee adds. "He showed in the very tough Super Rugby competition that he is a skilful player and a prolific goal-kicker and he covers both fullback and flyhalf. He can be very proud of his inclusion in the match-day squad as he matriculated from Grey Port Elizabeth just two years ago."
The Springboks are unbeaten at the Nelson Mandela Bay Stadium, with three wins and a draw dating back to 2011.
SPRINGBOK TEAM
15. Andries Coetzee (Emirates Lions), 3 caps, 0 points
14. Raymond Rhule (Toyota Cheetahs), 3 caps, 0 points
13. Jesse Kriel (Vodacom Bulls), 19 caps, 25 points (5t)
12. Jan Serfontein (Vodacom Bulls), 29 caps, 20 points (4t)
11. Courtnall Skosan (Emirates Lions), 3 caps, 0 points
10. Elton Jantjies (Emirates Lions), 14 caps, 130 points (1t, 22c, 27p)
9. Ross Cronje (Emirates Lions), 2 caps, 5 points (1 t)
8. Uzair Cassiem (Toyota Cheetahs) 1 cap, 5 points (1t)
7. Jaco Kriel (Emirates Lions), 8 caps, 0 points
6. Siya Kolisi (DHL Stormers), 19 caps, 5 points (1t)
5. Franco Mostert (Emirates Lions), 9 caps, 0 points
4. Eben Etzebeth (captain, DHL Stormers), 57 caps, 15 points (3t)
3. Coenie Oosthuizen (Cell C Sharks), 26, 20 points (4t)
2. Malcolm Marx (Emirates Lions), 5 caps, 5 points (1t)
1. Tendai Mtawarira (Cell C Sharks), 90 caps, 10 points (2t)
Replacements:
16. Bongi Mbonambi (DHL Stormers), 8 caps, 0 points
17. Steven Kitshoff (DHL Stormers), 13 caps, 0 points
18. Trevor Nyakane (Vodacom Bulls), 28 caps, 5 points (1t)
19. Pieter-Steph du Toit (DHL Stormers), 23 caps, 15 points (3t)
20. Jean-Luc du Preez (Cell C Sharks), 4 caps, 0 points
21. Francois Hougaard (Worcester Warriors, England), 42 caps, 25 points (5t)
22. Curwin Bosch (Cell C Sharks), uncapped
23. Damian de Allende (DHL Stormers), 22 caps, 15 points (3t)