The Big Ten enjoyed a successful opening week, with 10 wins in 12 nonconference games, losing by only respectable margins to returning Heisman Trophy winner Lamar Jackson of Louisville (Purdue) and 2016 College Football Playoff participant Washington (Rutgers).

The stakes rise a bit in Week 2, headlined, of course, by a visit from Oklahoma to face Ohio State on Saturday night (7:30 ET, ABC) and rivalries are rekindled in Pennsylvania and Iowa.

Visit our college football PickCenter page for additional information on these games and many more. Here’s our forecast for Week 2.

Northwestern at Duke, Saturday, noon, ESPNU

Dan Murphy: Had to pick at least one upset this week, and this is the best candidate. Northwestern looked shaky at times in its opening win over Nevada. Duke quarterback Daniel Jones can go toe-to-toe with Clayton Thorson in what should be a fun one in Durham, North Carolina. Duke 35, Northwestern 31

Mitch Sherman: Don’t put too much stock into the details of an opener. Remember two years ago, when the Wildcats beat Christian McCaffrey and Stanford in early September? Teams change, and they change fast at this time of year. I still believe in the Cats as a serious contender in the Big Ten West. Northwestern 35, Duke 24

Tom VanHaaren: This one is tough because I thought Northwestern was going to surprise a lot of people this season. Week 1 against Nevada was a win, but it wasn’t very convincing. Duke just threw up 60 on N.C. Central and had a relaxing time doing it. I’m George Costanza when it comes to predicting things; the opposite usually happens, but I’m sticking with the Wildcats. Northwestern 31, Duke 24

Iowa at Iowa State, Saturday, noon, ESPN2

Sherman: This series often defies logic. And sometimes it defines seasons, such as in 2012, when Iowa State last played in a bowl game. The Cyclones won that CyHawk thriller 9-6 en route to a magical 6-7 finish, while the Hawkeyes dipped to 4-8. There’s more magic in store for the Cyclones this year. Iowa State 17, Iowa 14

VanHaaren: I underestimated the Hawkeyes' defense in Week 1 and chose Wyoming over Iowa. Hawkeyes fans let me know about it, so I’m not making the same mistake twice. I’ll take Iowa on the road as long as the turnovers are minimal. Iowa 24, Iowa State 13

Murphy: The Hawkeyes' defense showed last week that there is a legitimate reason to believe in Iowa this season. They'll hold the Cyclones to 100 or so yards on the ground and provide plenty of cushion for the offense to bring home a win. Iowa 20, Iowa State 9

Pittsburgh at No. 4 Penn State, Saturday, 3:30 p.m., ABC

Murphy: Nothing in State College feels the same as it did a year ago, when the pitchforks were pointed at James Franklin after a loss to Pitt. The Nittany Lions are now the most entertaining offense in the Big Ten and have the firepower to blow past Pitt. Penn State 42, Pitt 24

VanHaaren: The last three home teams have won this game, and the last three teams with the most rushing yards have also won. Pitt won last season running behind James Conner. This season, it’s the Saquon Barkley show. The Nittany Lions are out to avenge last season’s loss. Penn State 38, Pitt 21

Sherman: Penn State is so much better than it was at this time last year. I have nothing else to add. Penn State 45, Pitt 17

Nebraska at Oregon, Saturday, 4:30 p.m., Fox

Sherman: Nebraska tried to play it safe last week, guarding against the big Arkansas State plays. Do that against the Ducks and Oregon will turn those short receptions into long touchdowns. I think Nebraska coach Bob Diaco’s defense will show up to play, but first-year QB Tanner Lee will wobble at a raucous Autzen Stadium. Oregon 37, Nebraska 27

VanHaaren: Oregon put up 77 on Southern Utah in the first week. I know it’s Southern Utah, but 77 is a lot of points. Nebraska won 43-36 against Arkansas State in its first game, so there are still some kinks to work out. This game is happening too early in the season for Nebraska. Oregon 52, Nebraska 41

Murphy: No need to overthink the math here. Oregon gained more than 700 yards in its season opener. The Huskers gave up 497. Lee won't be able to help them solve that problem. Oregon 44, Nebraska 36

No. 5 Oklahoma at No. 2 Ohio State, Saturday, 7:30 p.m., ABC

VanHaaren: Indiana attacked Ohio State’s corners last week, passing outside the hashes on 86 percent of QB Richard Lagow’s throws. Baker Mayfield ranks first in completion percentage, yards per attempt and touchdown percentage on throws outside the hashes, but I think Ohio State is going to learn from the first game and win this matchup with Oklahoma. Ohio State 42, Oklahoma 31

Murphy: The Buckeyes won this monster matchup a year ago thanks to their best deep-passing performance of the year. And while that's been a focus all offseason, it will be the uber-athletic front seven that helps them beat the Sooners this time around, doing just enough to contain Mayfield. Ohio State 30, Oklahoma 28

Sherman: The Sooners haven’t lost since Ohio State stormed Norman a year ago. Look for Oklahoma to start strong this time around. You might not see a college game this year that features better play in the trenches, especially when Oklahoma possesses the ball. Watch that matchup. I agree with Dan that the Buckeyes will eventually get to Mayfield. Ohio State 34, Oklahoma 31

Other games

• Purdue over Ohio

• Maryland over Towson

• No. 9 Wisconsin over Florida Atlantic

• No. 8 Michigan over Cincinnati

• Michigan State over Western Michigan

• Rutgers over Eastern Michigan

• Indiana over Virginia

• Western Kentucky over Illinois

• Minnesota over Oregon State