Adelaide have swung the selection axe, while Rory Laird and Tom Lynch have failed to prove their fitness for the massive AFL clash with Hawthorn.
While the slumping Crows have dropped three players, Richmond have named Dustin Martin and Daniel Rioli in their squad for Sunday's big MCG match against Geelong.
Jack Billings' VFL demotion lasted one week, with his 54 possessions prompting an immediate recall at St Kilda.
Star trio Nat Fyfe, Aaron Sandilands and Stephen Hill will return for Fremantle but Sydney veteran Jarrad McVeigh (calf) and West Coast defender Tom Barrass (back) are out of Friday night's SCG blockbuster.
The Crows had hoped Laird (hand) and Lynch (side strain) might recover in time.
While Luke Brown (ankle) was a known casualty, Adelaide dropped Cam Ellis-Yolmen, Darcy Fogarty and Lachlan Murphy on the back of a three-game losing streak.
Patrick Wilson will debut, while Andy Otten, Kyle Cheney and Jordan Gallucci are recalled.
It will be Cheney's first senior game since the 2016 finals.
Hawthorn recalled Will Langford for Tim O'Brien.
Martin, Rioli and fellow premiership player Jack Graham are among six additions to the squad for Sunday's game, with the team to be confirmed on Friday.
Martin missed last week with a calf injury and Rioli has not played in the AFL since breaking his foot during their grand final win.
Ryan Garthwaite will debut if picked and the Tigers also put Corey Ellis and Ivan Saldo in their squad.
Anthony Miles and Connor Menadue were dropped.
The Cats lost Aaron Black to a knee reconstruction and added Jackson Thurlow - his likely replacement - Cory Gregson, Zach Guthrie, Lincoln McCarthy and Sam Simpson.
Apart from Billings, the Saints named David Armitage for his first senior game in almost a month.
They made four unforced changes for the away match on Saturday against Gold Coast, billed as the crisis cup given the poor form of the two teams.
Jake Carlisle and Billy Longer also return for St Kilda, who dropped Nick Coffield, Tom Hickey, Jack Lonie and Ed Phillips.
Jarryd Lyons is back in the Suns' line-up for the first time since round nine.
Gold Coast also named Sean Lemmens and Josh Schoenfeld, with Will Brodie, Jacob Heron and Brad Scheer axed.
Apart from losing McVeigh, the Swans dropped Dan Robinson and recalled Kieren Jack and Aliir Aliir.
Eagles forward Liam Ryan is back for his first match at any level since an ankle injury in round three.
Jarrod Brander will debut, while Luke Shuey and Chris Masten return.
Barrass, who would have played on Lance Franklin, is a major loss.
Jack Darling (ankle), Mark Hutchings and Brandon Ah Chee are the other omissions.
Fyfe, Sandilands and Hill are Fremantle's three inclusions for Saturday's Etihad Stadium match against Carlton.
Michael Walters is suspended, Alex Pearce has a broken thumb and Scott Jones was dropped.
The Blues named Levi Casboult and Nick Graham for Cameron O'Shea and David Cunningham (toe).