Greater Western Sydney's Jeremy Cameron will play no further part in the AFL finals, while injured ruckman Shane Mumford may also be an enforced omission this week.
Cameron suffered a hamstring injury in Thursday night's qualifying final loss to Adelaide, with GWS co-captain Callan Ward confirming on Monday the key forward would not return this year.
Mumford is seeing a foot specialist, with the club set to provide an update later on Monday. He is far from a certain starter for Saturday's home semi-final against West Coast.
Ward admitted Cameron's third hamstring setback in the space of two months was "very disappointing" news but praised the young gun's attitude.
"He's been up and about, I think he knows the importance of him being positive around the group," Ward told reporters.
"The last thing the boys want to see is a guy walking around with his head between his legs, so I think he's being really positive.
"It's a tough situation for him to be told his season is done, especially at this time of the year."
Ward backed the Giants' rejigged forward line to function just as well without Cameron.
"Jez is a super player and has been for a few years now," he said.
"I love playing with Jez but I still believe we can play really good footy without him."
The midfielder was likewise upbeat that former Geelong ruckman Dawson Simpson, who has played two AFL games since joining the Giants after the 2015 season, could step up if required against the Eagles.
"Dawson came in and played a couple of games for us this year and played a really good role for us, so I've got full confidence in Dawson," Ward said.
Injuries have threatened to derail the Giants' season at various points of this year.
Ward noted fit-again veteran Ryan Griffen would be in the mix to tackle West Coast, likewise Devon Smith and Steve Johnson.